Crystalline forms of ertapenem sodium
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: 1 characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution contain...
Saved in:
Main Authors | , , , , , , , , , |
---|---|
Format | Patent |
Language | English |
Published |
25.11.2004
|
Online Access | Get full text |
Cover
Loading…
Abstract | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa:
1
characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C
2-5
alcohol at between −5 and −25° C. |
---|---|
AbstractList | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa:
1
characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C
2-5
alcohol at between −5 and −25° C. |
Author | Ward, Michael Crocker, Louis Wenslow, Robert Sidler, Daniel Cvetovich, Raymond Fisher, Elizabeth Mahajan, Amar Brands, Karel Orella, Charles Williams, John |
Author_xml | – sequence: 1 givenname: Karel surname: Brands fullname: Brands, Karel – sequence: 1 givenname: Raymond surname: Cvetovich fullname: Cvetovich, Raymond – sequence: 2 givenname: Louis surname: Crocker fullname: Crocker, Louis – sequence: 3 givenname: Michael surname: Ward fullname: Ward, Michael – sequence: 4 givenname: Amar surname: Mahajan fullname: Mahajan, Amar – sequence: 5 givenname: Robert surname: Wenslow fullname: Wenslow, Robert – sequence: 6 givenname: John surname: Williams fullname: Williams, John – sequence: 7 givenname: Daniel surname: Sidler fullname: Sidler, Daniel – sequence: 8 givenname: Charles surname: Orella fullname: Orella, Charles – sequence: 9 givenname: Elizabeth surname: Fisher fullname: Fisher, Elizabeth |
BookMark | eNrjYmDJy89L5WRQdS6qLC5JzMnJzEtVSMsvyi1WyE9TSC0qSSxIzUvNVSjOT8kszeVhYE1LzClO5YXS3Ayabq4hzh66pcUFiSWpeSXF8YkFBTmZyYklmfl5xfFGBgYmBkbGphaG5sakqAUAbu0wMg |
ContentType | Patent |
DBID | EFI |
DatabaseName | USPTO Published Applications |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EFI name: USPTO Published Applications url: http://www.uspto.gov/patft/index.html sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
ExternalDocumentID | 20040235817 |
GroupedDBID | EFI |
ID | FETCH-uspatents_applications_200402358173 |
IEDL.DBID | EFI |
IngestDate | Sun Mar 05 22:29:49 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-uspatents_applications_200402358173 |
OpenAccessLink | https://patentcenter.uspto.gov/applications/10485319 |
ParticipantIDs | uspatents_applications_20040235817 |
PublicationCentury | 2000 |
PublicationDate | 20041125 |
PublicationDateYYYYMMDD | 2004-11-25 |
PublicationDate_xml | – month: 11 year: 2004 text: 20041125 day: 25 |
PublicationDecade | 2000 |
PublicationYear | 2004 |
Score | 2.612218 |
Snippet | A process for preparing a crystalline, carbapenem monosodium salt of formula IIa:
1
characterized by the steps a) adding about 10 to 30% of an organic solvent... |
SourceID | uspatents |
SourceType | Open Access Repository |
Title | Crystalline forms of ertapenem sodium |
URI | https://patentcenter.uspto.gov/applications/10485319 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQMU81SEo0Ak2rp5hZ6JoYp6TqJhknpepamielmFsmWZgZmIM2OPv6mXmEmnhFmEZAN4WB9sIUAFtYeSWghYmpRXqlxQUl-eDVlSizucAehAUo6TAzMFuYg7s8bp7cDJxA1WDNxUgVhJsgA1sAWFSIgSk1T4RB1bmoEtjsAp13naoAahYWK-SnKYDmvQuAZUuuQnF-SmZpriiDpptriLOHLtzMeGQXgO5uNAEdFGNhaG4sxsAC7KinSjAoWKSaJBonGiQCK3VLE2BNmWiQZm5ilpacaGxolmZilCbJoETYPCliFEkzcEEOHDTUNTKVYWApKSpNlQVWjiVJcuDQAAA-EW7e |
link.rule.ids | 230,308,780,873,885,64059 |
linkProvider | USPTO |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjVxLS8QwEB50FR8nRUXXVxE9eIj2kU3a82rZ9bH0oLC3kpgEFuyDbYvsv3fSivSm1xCGIUPm-8KX-QCuuXal8K2srlhIaKA0kYHUJOJS8UiGzOV2wPl1xibv9Gk-mv-MR7ezMBleI1JiLtVdU5V10X6uxPbeFZ505s_WIzC37gNf-WchVKLMva229W4JPb4OGwx5SEsj4-kubGMgJG55XfWgI96DzaRd3Yc1nR_AzXi5QkJmnbC1Ywlj5RTGsYp4iV0nc6pCLZrsEG7jx7fxhPzGTPtKc9pLIziCAT7h9TE4oaYiEK5AuI8oYqhwDafMfIjAY4b65gSu_o43_M-mS9hKHuL0ZTp7PoWdzpXQI_7oDAb1stHniKC1vGgP5hvbBXoh |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Crystalline+forms+of+ertapenem+sodium&rft.inventor=Brands%2C+Karel&rft.inventor=Cvetovich%2C+Raymond&rft.inventor=Crocker%2C+Louis&rft.inventor=Ward%2C+Michael&rft.inventor=Mahajan%2C+Amar&rft.inventor=Wenslow%2C+Robert&rft.inventor=Williams%2C+John&rft.inventor=Sidler%2C+Daniel&rft.inventor=Orella%2C+Charles&rft.inventor=Fisher%2C+Elizabeth&rft.date=2004-11-25&rft.externalDBID=n%2Fa&rft.externalDocID=20040235817 |