Modified factor VII

The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. The modified Factor VII may be used in conjunction with stents to inhibi...

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Bibliographic Details
Main Authors Berkner, Kathleen, Petersen, Lars, Hart, Charles, Hedner, Ulla, Bregengaard, Claus
Format Patent
LanguageEnglish
Published 07.10.2004
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Summary:The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. The modified Factor VII may be used in conjunction with stents to inhibit coagulation, vascular restenosis, and/or platelet deposition.