Process for preparing erythromycin compound

The present invention is to provide a process for producing an erythromycin compound by subjecting a 2′-O-acetyl-4″-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound 1 to alkylation, which comprises reacting Compound 1 with an alkylating agent in the presence of a base in a mixed solv...

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Bibliographic Details
Main Authors Miyata, Hiroyuki, Takama, Akira, Kawaguchi, Tatsuya, Sakata, Kazuma, Ataka, Kikuo, Oku, Masayoshi
Format Patent
LanguageEnglish
Published 30.09.2004
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Summary:The present invention is to provide a process for producing an erythromycin compound by subjecting a 2′-O-acetyl-4″-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound 1 to alkylation, which comprises reacting Compound 1 with an alkylating agent in the presence of a base in a mixed solvent of 0.18 to 1.05 equivalent of water based on Compound 1 and an organic solvent to give a 2′-O-acetyl-4″-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound 3.