Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I 1 wherein: -A-A- represents the group -CHR 4 -CHR 5 - or CR 4 CR 5 - R 3 , R 4 and R 5 are independently selected from the group consisting o...

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Main Authors Wang, Ping, Ng, John, Baez, Julio, Liu, Chin, Anderson, Dennis, Lawson, Jon, Erb, Bernhard, Wieczorek, Joseph, Mucciariello, Gennaro, Vanzanella, Fortunato, Kunda, Sastry, Letendre, Leo, Pozzo, Mark, Sing, Yuen-Lung, Yonan, Edward
Format Patent
LanguageEnglish
Published 30.09.2004
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Summary:Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I 1 wherein: -A-A- represents the group -CHR 4 -CHR 5 - or CR 4 CR 5 - R 3 , R 4 and R 5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R 1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical, -B-B- represents the group -CHR 6 -CHR 7 - or an alpha- or beta-oriented group: 2 where R 6 and R 7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R 8 and R 9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R 8 and R 9 together comprise a carbocyclic or heterocyclic ring structure, or R 8 or R 9 together with R 6 or R 7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.