Anti-cd3 single-chain antibodies having human cmu3 and cmu4 domains

The invention relates to a single-chain antibody which is characterized in that (a) it contains a variable domain (scFv) binding specifically to human CD3, and (b) its constant domains are derived from a human IgM molecule and comprise the C 3 domain and the C 4 domain but not the C 1 domain and the...

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Bibliographic Details
Main Authors Little, Melvyn, Choi, Ingrid, Sandlie, Inger
Format Patent
LanguageEnglish
Published 09.09.2004
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Summary:The invention relates to a single-chain antibody which is characterized in that (a) it contains a variable domain (scFv) binding specifically to human CD3, and (b) its constant domains are derived from a human IgM molecule and comprise the C 3 domain and the C 4 domain but not the C 1 domain and the C 2 domain. In a preferred embodiment, the antibody according to the invention contains a human IgG 3 hinge region between the variable and constant domains. The invention also relates to DNA sequences coding for this antibody and to expression vectors containing these DNA sequences and finally to preparations containing the above compounds, preferably for the prevention of acute rejection reactions following organ transplantation.