Methods

The invention provides a method for the detection of a polymorphism in OATPB in a human which method comprises determining the sequence of the human at one of the following positions: position (1113) of SEQ ID NO: 4 and/or position (312) of SEQ ID NO: 5. The polymorphism at position (1113) is presen...

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Bibliographic Details
Main Author Moore, Rachael
Format Patent
LanguageEnglish
Published 02.09.2004
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Summary:The invention provides a method for the detection of a polymorphism in OATPB in a human which method comprises determining the sequence of the human at one of the following positions: position (1113) of SEQ ID NO: 4 and/or position (312) of SEQ ID NO: 5. The polymorphism at position (1113) is presence of G and/or A and the polymorphism at position (312) is presence of Arg and/or Gln. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of a drug transportable by OATB.