Method for producing double-crosslinked hyaluronate material

A method for producing a double-crosslinked hyaluronate material. A hyaluronic acid or a salt thereof is sequentially reacted with an epoxide compound and a carbodiimide compound to produce a more biodegradation-resistant hyaluronate material.

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Bibliographic Details
Main Authors Tsai, Shiao-Wen, Yang, Chiung-Lin, Chen, Jui-Hsiang, Chang, Pei-Ching, Su, Li-Ting, Jan, Shu-Hua
Format Patent
LanguageEnglish
Published 01.07.2004
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Summary:A method for producing a double-crosslinked hyaluronate material. A hyaluronic acid or a salt thereof is sequentially reacted with an epoxide compound and a carbodiimide compound to produce a more biodegradation-resistant hyaluronate material.