Prion disinfection

The invention relates to a methods and compositions for treating a surface, suspension or solution contaminated with a PrP Sc prion protein or a surrogate thereof. The methods and compositions employ a combination of one or more enzymes effective to cleave a prion protein to fragments having a non-i...

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Bibliographic Details
Main Authors Sava, Alex, Kritzler, Steven, Zalunardo, Michael
Format Patent
LanguageEnglish
Published 03.06.2004
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Summary:The invention relates to a methods and compositions for treating a surface, suspension or solution contaminated with a PrP Sc prion protein or a surrogate thereof. The methods and compositions employ a combination of one or more enzymes effective to cleave a prion protein to fragments having a non-infective molecular weight, and one or more agents selected to favour conformational unfolding of the PrP Sc prion protein while not denaturing the one or more enzymes.