Process for the preparation of 9-beta-anomeric nucleoside analogs

• Main Authors: Gupta, Pranab, Munk, Stephen
• Format: Patent
• Language: English
• Published: 26.02.2004

A process for substantially enhancing the regio and stereoselective synthesis of 9- -anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9- -D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′- -fluoro and 2′,3′-dideoxy-2′- -fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.