Universal signal amplification tail

The present invention resides in a detection agent that can be used to amplify a detection signal for a target molecule. The detection agent contains a linear first single-stranded nucleic acid attached to a capture moiety that specific binds the target molecule of interest. The first single-strande...

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Bibliographic Details
Main Authors Liu, Jason, Breneman, John, Carillo, Arlene, Hixson, Craig
Format Patent
LanguageEnglish
Published 01.01.2004
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Summary:The present invention resides in a detection agent that can be used to amplify a detection signal for a target molecule. The detection agent contains a linear first single-stranded nucleic acid attached to a capture moiety that specific binds the target molecule of interest. The first single-stranded nucleic acid includes a plurality of repeat sequences, each of which is non-homopolymeric and can specifically bind to a second single-stranded nucleic acid that has at least one detectable label. Related method for using the claimed detection agent to amplify a detection signal and a kit for this purpose are also disclosed.