Synthesis of epothilones, intermediates thereto and analogues thereof

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilo...

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Main Authors Bertinato, Peter, Danishefsky, Samuel, Su, Dai-Shi, Meng, DongFang, Chou, Ting-Chao, Kamenecka, Ted, Sorensen, Erik, Balog, Aaron, Savin, Kenneth, Kuduk, Scott, Harris, Christina, Zhang, Xiu-Guo, Bertino, Joseph
Format Patent
LanguageEnglish
Published 06.11.2003
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Summary:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.