Indolizine compounds

This invention relates to compounds of Formula (I) 1 wherein Ring A, X, Y, Z, R 1 , R 2 and R 3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This inv...

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Bibliographic Details
Main Authors Ono, Mitsunori, Przewloka, Teresa, James, David, Chimmanamada, Dinesh, Lu, Rongzhen, Nagai, Masazumi, Koya, Keizo, Sun, Lijun
Format Patent
LanguageEnglish
Published 30.10.2003
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Summary:This invention relates to compounds of Formula (I) 1 wherein Ring A, X, Y, Z, R 1 , R 2 and R 3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention also relates to pharmaceutical compositions comprising at least one compound of Formula (I) and methods for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines.