Tricyclic inhibitors of poly(ADP-ribose) polymerases

Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. 1 As cancer therapeutics, the compounds of the invention may be used, e...

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Bibliographic Details
Main Authors Canan-Koch, Stacie, Webber, Stephen, Tikhe, Jayashree, Thoresen, Lars
Format Patent
LanguageEnglish
Published 24.04.2003
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Summary:Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. 1 As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.