Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents

Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bi...

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Main Authors Ohtsuka, Yasuo, Nishizuka, Toshio, Shiokawa, Sohjiro, Tsutsumi, Seiji, Kawaguchi, Mami, Kitagawa, Hideo, Takata, Hiromi, Shishikura, Takashi, Ishikura, Toyoaki, Fushihara, Kenichi, Okada, Yumiko, Miyamoto, Sachiko, Shiobara, Maki
Format Patent
LanguageEnglish
Published 26.09.2002
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Summary:Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. 1 wherein R 1 represents hydrogen, OH, alkyl or phenyl alkyl, R 2 , R 3 , R 4 , and R 5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy: 2