32591, a novel human GTPase activating molecule and uses therefor

The invention provides isolated nucleic acids molecules, designated GAP-5 nucleic acid molecules, which encode a novel family of GTPase activating proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GAP-5 nucleic acid molecules, host cell...

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Bibliographic Details
Main Author Meyers, Rachel
Format Patent
LanguageEnglish
Published 04.07.2002
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Summary:The invention provides isolated nucleic acids molecules, designated GAP-5 nucleic acid molecules, which encode a novel family of GTPase activating proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GAP-5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GAP-5 gene has been introduced or disrupted. The invention still further provides isolated GAP-5 proteins, fusion proteins, antigenic peptides, and anti-GAP-5 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.