Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

Compounds of the formula: 1 where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or h...

Full description

Saved in:
Bibliographic Details
Main Authors Chu, Shao, Johnson, Jr, Theodore, Eastman, Brian, Hua, Ye, Luu, Hiep, Reich, Siegfried, Skalitzky, Donald, Yang, Yi, Hendrickson, Thomas, Chan, Fora
Format Patent
LanguageEnglish
Published 23.05.2002
Online AccessGet full text

Cover

More Information
Summary:Compounds of the formula: 1 where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.