Transcripts of the MHC class I HLA-G gene and their applications

Transcripts of the major histocompatibility complex (MHC) Class I HLA-G gene which are present in foetal trophoblasts and/or in adult circulating mono-nuclear cells, as well as their applications. Either the said transcripts comprise, in succession in the 5′ to 3′ direction: a fragment encoding the...

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Main Authors Carosella, Edgardo, Moreau, Philippe, Gluckman, Elaine, Kirszenbaum, Marek
Format Patent
LanguageEnglish
Published 02.05.2002
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Summary:Transcripts of the major histocompatibility complex (MHC) Class I HLA-G gene which are present in foetal trophoblasts and/or in adult circulating mono-nuclear cells, as well as their applications. Either the said transcripts comprise, in succession in the 5′ to 3′ direction: a fragment encoding the signal peptide (exon 1), a fragment encoding the 1 domain (exon 2), a fragment encoding the 2 domain (exon 3), a fragment encoding the trans-membrane TM domain (exon 5), a fragment encoding the cytoplasmic domain (exon 6) and the 3′ untranslated fragment (exon 8), which sequence is designated HLA-G4, or the said transcripts comprise intron 4.