Methods for increasing levels of acetylcholine

The current invention relates to a method for increasing levels of acetylcholine in mammals comprising administering to a mammal in need thereof, an effective amount of a compound of formula I: 1 wherein either R 1 is H or a lower alkyl radical and R 2 is a lower alkyl radical, or R 1 and R 2 are jo...

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Bibliographic Details
Main Authors Bryant, Henry, Paul, Steven, Wu, Xin, Glinn, Michele
Format Patent
LanguageEnglish
Published 15.11.2001
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Summary:The current invention relates to a method for increasing levels of acetylcholine in mammals comprising administering to a mammal in need thereof, an effective amount of a compound of formula I: 1 wherein either R 1 is H or a lower alkyl radical and R 2 is a lower alkyl radical, or R 1 and R 2 are joined together with the adjacent nitrogen atom to form a heterocyclic radical; R 3 is H or a lower alkyl radical; R 4 is H, halo, OH, a lower alkyl radical, or is a buta-1,3-dienyl radical which together with the adjacent benzene ring forms a naphthyl radical; R 5 is H or OH; and n is 2; or a pharmaceutically acceptable salt thereof and optionally an AChE inhibitor.