Method for identifying a site of protein-protein interaction for the rational design of short peptides that interfere with that interaction

• Format: Patent
• Language: English
• Published: 15.02.2005

The invention provides a method for identifying a site of protein-protein interaction in a polypeptide. In general, the method involves calculating the difference in property scores between amino acids of a corresponding pair of amino acids on two homologous polypeptides, and identifying a window of contiguous amino acids that have a significant difference in property scores. The contiguous amino acids are predicted to be sites of protein-protein interactions. The invention provides computer systems for performing the methods. The subject methods and computer systems find application in identifying modulators of protein-protein interactions that can serve as inhibitors or activators of the protein from which it was derived, and, as such, find use in a variety or medical and research applications, including drug discovery.