New Insights of Neuromedin B and its Receptor NMBR Involvement in Immunity

Neuromedin B (NMB) is a member of mammalian bombesin-like peptide family and almost all its potent biological actions take place exclusively through its receptor NMBR, which has been identified as a G-protein couple receptor with seven trans-membrane regions. NMB and NMBR represent an interesting si...

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Published inAsian agricultural research Vol. 13; no. 6; pp. 42 - 47
Main Authors LI, Chunyu, MA, Yijie, TIAN, Shimao, WAN, Qianhui, TANG, Mengyao, NING, Hongya, MA, Shujie, YANG, Guihong
Format Journal Article
LanguageEnglish
Published 20.06.2021
Edition1812
Subjects
Agribusiness
Neuromedin B/NMBR, Cell proliferation, Tumorigenesis, Angiogenesis, Neurogenic inflammation, Influenza A virus
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Summary:Neuromedin B (NMB) is a member of mammalian bombesin-like peptide family and almost all its potent biological actions take place exclusively through its receptor NMBR, which has been identified as a G-protein couple receptor with seven trans-membrane regions. NMB and NMBR represent an interesting signaling axis over which NMB/NMBR perform multiple biological activities, in particularly, they have been highlighted in the regulation of the immunology system. This review aims to provide a brief overview of the recent advancements in our understanding regarding the potential immunological functions of NMB and NMBR in cell proliferation, tumorigenesis, angiogenesis, neurogenic inflammation, anti-influenza A virus (IAV) infections, and briefly discusses the potential importance of these observations. All these implicated that targeting NMBR or developing analogues of NMB may represent a useful strategy for development of new anti-IAV agents.
ISSN:1943-9903
DOI:10.22004/ag.econ.316957