Mesane kanseri tanısında serum Ca 19-9 ve Ca 125 düzeylerinin rolü

• Published in: Cerrahpaşa tıp dergisi Vol. 35; no. 1; pp. 18 - 22
• Main Authors: ÖZKAN, Burak, HAMELİ, Hüseyin, ERÖZENCİ, Ahmet, SOLOK, Vural
• Format: Journal Article
• Language: Turkish
• Published: İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi 2004
• Subjects: Biological Factors; Biyolojik faktörler; Breast Neoplasms; CA-125 Antigen; CA-125 antijen; CA-19-9 Antigen; CA-19-9 antijen; Diagnosis; Diagnostic Techniques and Procedures; Meme neoplazmları; Neoplasms; Neoplazmlar; Tanı; Tanı teknikleri ve prosedürler
• ISSN: 1300-5227

Background and design: A non-invasive marker test for bladder carcinoma would not only decrease the cost, but also improve patient quality of life. For bladder carcinoma, tumor growth or invasion associated mo¬lecules may serve as. markers and they may be detected non-invasively. Carbonhydrate antigen (CA) 19-9 and 125 are useful tumor markers for huroan cancer, especially in gastrointestinal and gynecologic malignen-cies. In this study, our aim is to determine the efficiancy of serum CA 19-9 and 125 levels for the detection of bladder carcinoma different from other studies. For this purpose, serum samples were obtained from 49 pati¬ents with bladder carcinoma and from 24 patients with benign prostate hyperplasia and 23 patients with nephrolithiasis. Approximately 2 ml serum sample was obtained and aliquated for electro-chemiluminesence immunoassay. Results: CA 19-9 was determined as positive for 6 patients in bladder carcinoma group. It was positive for 1 patient in the benign prostate hyperplasia and for 4 patients in the nephrolithiasis group (p > 0.05). CA 125 was determined as positive for only one patient in the bladder carcinoma group. 4 patients in the nephrolithi¬asis group had positive CA 125 level (p > 0.05). The overall sensitivity and specifity were % 12.2 and % 89.4 for CA 19-9. CA 125 has % 2 sensitivity and %91.5 specificity for bladder carcinoma. Conclusion: In the population tested, serum CA 19-9 and CA 125 determined as not effective in the diagno¬sis of bladder carcinoma with regard to the sensitivity and specifity values and they could not offer more sen¬sitivity than the other tumor markers and/or cytology for bladder carcinoma.