Continuous heparin infusion and in-line filter in peripherally placed percutaneous central venous catheters

• Published in: Zeitschrift für Geburtshilfe und Neonatologie
• Main Authors: Döll, C, Brotschi, B, Frey, B, Hug, M, Ersch, J, Bernet, V
• Format: Conference Proceeding
• Language: English
• Published: 24.04.2009
• Subjects: central venous line; in-line filter; newborn
• ISSN: 0948-2393; 1439-1651
• DOI: 10.1055/s-0029-1222781

Objective: To evaluate the effectiveness of heparin combined with in-line filters for the reduction of occlusion rate, increase of elective catheter removal and prolongation of catheter life time of peripherally placed percutaneous central venous catheters (PCVCs) in neonates. Study design: Prospective observational study in neonates with PCVC, comparing heparin (1 IU/ml) combined with in-line filters versus no heparin/no in-line filters. Primary objectives were to evaluate the rate of catheter occlusion and elective catheter removal. Secondary objectives were the evaluation of catheter life time and rates of phlebitis, thrombosis, extravasation and catheter related sepsis. Results: A total of 71 neonates (80 catheters, 40 in each group) were included in the study. The incidence of catheter occlusion was statistically significantly lower in the heparin/in-line filter group versus no heparin/no in-line filter group (5% versus 22.5%). Although the incidence of elective catheter removal was statistically significantly higher in the heparin/in-line filter group (85% versus 60%), there was no statistically significant difference in catheter life time in both groups 8.9±4.9 versus 10.78±6.6 days. Conclusions: Low dose heparin as a continuous infusion combined with in-line filters increased the rate of elective catheter removal after completion of therapy and reduced the incidence of catheter occlusion without increasing adverse effects in term and preterm neonates.