Interaction of mutant genes Fgf5go-Y, we, and wal changes the duration of hair growth cycles in mice

Mutant gene wallhaarig ( wa ) was acting as a modifier of the mutant gene waved alopecia ( wal ), substantially increasing hair loss rate in mice, as was previously shown in our laboratory. The current paper is devoted to a study of mutant gene angora-Y ( Fgf5 go-Y ), which had extended anagen stage...

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Bibliographic Details
Published inRussian journal of developmental biology Vol. 43; no. 1; pp. 54 - 59
Main Authors Nesterova, A. P., Nizamutdinov, I. I., Konyukhov, B. V.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 2012
Subjects
Animal Anatomy
Biomedical and Life Sciences
Developmental Biology
Developmental Genetics
Histology
Life Sciences
Morphology
alopecia
mutant mice
catagen
anagen
telogen
hair follicle cycles
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Summary:Mutant gene wallhaarig ( wa ) was acting as a modifier of the mutant gene waved alopecia ( wal ), substantially increasing hair loss rate in mice, as was previously shown in our laboratory. The current paper is devoted to a study of mutant gene angora-Y ( Fgf5 go-Y ), which had extended anagen stage of the first and second generations hair growth cycles in triple heterozygotes ( Fgf5 go-Y / Fgf5 go-Y we/we wal/wal ). First generation guard hair in triple homozygotes had their anagen stage 4 days longer than the same stage in double homozygotes (+/+ we/we wal/wal ). Hair loss started at a catagen stage in double homozygotes, while it started in triple homozygotes at the end of the same stage or even in a telogen. Such mutant gene interaction in hair follicle morphogenesis led to a partial recovery of a body hair coat in triple homozygotes.
ISSN:1062-3604
1608-3326
DOI:10.1134/S1062360412010031