Natural Populations of Galphimia spp. Attenuates InVitro and InVivo Inflammatory Responses
The genus Galphimia , Malpighiaceae, is widely distributed in Mexico and represented by 22 species including medicinal species. The sedative and anti-inflammatory effects of galphimines produced by the species Galphimia glauca Cav. have been documented. Formerly, molecular studies using DNA barcodes...
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Published in | Revista brasileira de farmacognosia Vol. 32; no. 6; pp. 1025 - 1032 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
2022
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Subjects | |
Online Access | Get full text |
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Summary: | The genus
Galphimia
, Malpighiaceae, is widely distributed in Mexico and represented by 22 species including medicinal species. The sedative and anti-inflammatory effects of galphimines produced by the species
Galphimia glauca
Cav. have been documented. Formerly, molecular studies using DNA barcodes demonstrated that nine populations botanically classified as
G. glauca
belong to four different species of the genus
Galphimia
and that only one exhibited the sedative properties; however, all the collected species showed anti-inflammatory activity. The aim of this work was to determine the anti-inflammatory activity of methanolic extracts of nine
Galphimia
spp. populations grown in Mexico. The possible modes of action were analyzed by evaluating the inhibition of LPS-induced inflammation processes both
in vitro
and
in vivo
. Using RAW 264.7 murine macrophage cells, all extracts significantly reduced the nitrite production. Thus, the possible relevance of galphimines was studied. One galphimine-producer population and one galphimine-non-producer population were selected, and their anti-inflammatory potential against systemic and central LPS-induced inflammation in mice was evaluated. In the periphery, both populations significantly reduced macrophage and dendritic cell activation. Similarly, both extracts reduced Iba1 expression in the hippocampus. Therefore, the presence of galphimines did not mediate the observed anti-inflammatory effects.
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ISSN: | 1981-528X |
DOI: | 10.1007/s43450-022-00325-y |