High-yield production of short chain length poly(ε-l-lysine) consisting of 5–20 residues by Streptomycesaureofaciens, and its antimicrobial activity

Poly(ε- l -lysine) (ε-PL) is a naturally-occurring l -lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length ε-PL consisting of 5–20 residues at the highest production level of 4.5 g l –1 . This ε-PL had different spectra...

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Bibliographic Details
Published inBiotechnology letters Vol. 32; no. 9; pp. 1299 - 1303
Main Authors Takehara, Munenori, Hibino, Atsushi, Saimura, Masayuki, Hirohara, Hideo
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 2010
Subjects
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Life Sciences
Microbiology
Original Research Paper
lysine
Antimicrobial activity
Chain length
Metabolic pathways
Poly(ε
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Summary:Poly(ε- l -lysine) (ε-PL) is a naturally-occurring l -lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length ε-PL consisting of 5–20 residues at the highest production level of 4.5 g l –1 . This ε-PL had different spectra in terms of antimicrobial activity from the ε-PL that is now used as a food preservative. The high productivity was based on multiple metabolic pathways for l -lysine synthesis, and a great flux from l -lysine to ε-PL. The usefulness of this new ε-PL and its producing strain was discussed.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-010-0294-9