Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017 Recombinant echovirus 30 causing aseptic meningitis in Japan

A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this ou...

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Published inArchives of virology Vol. 165; no. 2; pp. 433 - 438
Main Authors Miyoshi, Masahiro, Goto, Akiko, Komagome, Rika, Yamaguchi, Hiroki, Maruo, Yuji, Nakanishi, Masanori, Ishida, Setsuko, Nagano, Hideki, Sugisawa, Takahisa, Okano, Motohiko
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.02.2020
Subjects
Biomedical and Life Sciences
Biomedicine
Brief Report
Infectious Diseases
Medical Microbiology
Virology
Aseptic meningitis
Genetic characterization
Outbreak
Genome recombination
Echovirus 30
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Summary:A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this outbreak. Phylogenetic analysis of the viral capsid protein 1 gene showed that the strains were most closely related to E30 strains detected in Germany, France, and Russia in 2013. In contrast, the region encoding the viral protease and the RNA-dependent RNA polymerase had a close phylogenetic relationship to non-E30 enteroviruses detected in the United Kingdom and Switzerland in 2015-2017, suggesting that a recombination event had occurred.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-019-04484-7