Three-dimensional pointwise comparison of human retinal optical property at 845 and

• Published in: Journal of Biomedical Optics Vol. 14; no. 2; pp. 024016 - 024015
• Main Authors: Chen, Yueli, Burnes, Daina L, de Bruin, Martijn, Mujat, Mircea, de Boer, Johannes F
• Format: Journal Article
• Language: English
• Published: 28.04.2009
• Subjects: image segmentation and registration; optical coherence tomography; optical frequency domain imaging; optical scattering and absorption; retina
• ISSN: 1083-3668; 1560-2281
• DOI: 10.1117/1.3119103

To compare the optical properties of the human retina, 3-D volumetric images of the same eye are acquired with two nearly identical optical coherence tomography (OCT) systems at center wavelengths of 845 and using optical frequency domain imaging (OFDI). To characterize the contrast of individual tissue layers in the retina at these two wavelengths, the 3-D volumetric data sets are carefully spatially matched. The relative scattering intensities from different layers such as the nerve fiber, photoreceptor, pigment epithelium, and choroid are measured and a quantitative comparison is presented. OCT retinal imaging at is found to have a significantly better depth penetration but a reduced contrast between the retinal nerve fiber, the ganglion cell, and the inner plexiform layers compared to the OCT retinal imaging at .