Diagnosis of monoclonal gammopathy of renal significance

Monoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone. The term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the...

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Bibliographic Details
Published inPortuguese journal of nephrology & hypertension Vol. 32; no. 1; pp. 52 - 56
Main Authors Correia, Sofia O, Santos, Sofia, Martins, La Salete, Santos, Josefina
Format Journal Article
LanguagePortuguese
Published Sociedade Portuguesa de Nefrologia 01.03.2018
Subjects
UROLOGY & NEPHROLOGY
treatment
Monoclonal gammopathy of renal significance
renal pathology
M protein
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Summary:Monoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone. The term monoclonal gammopathy of renal significance (MGRS) was introduced to distinguish monoclonal gammopathies that result in the development of kidney disease from those that are benign. Screening for monoclonal immunoglobulin and an appropriate hematologic workup are fundamental and sometimes a difficult challenge, with therapeutic and prognostic implications. Kidney biopsy is essential to determine the exact nature of the lesion and to evaluate the severity of renal disease. In this review we discuss the clinical and pathologic features of MGRS, highlighting the most diagnostic difficulties and current therapeutic options
ISSN:0872-0169