Renal sarcoidosis presenting as renal failure: report of three cases with interstitial nephritis and normocalcemia

Sarcoidosis is a chronic inflammatory disorder of unknown cause. The histopathological feature is the presence of the non-caseating granuloma in any organ involved. The mechanisms most frequently implicated in renal dysfunction are due to disturbances in calcium metabolism; more rarely, granulomatou...

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Published inPortuguese journal of nephrology & hypertension Vol. 27; no. 4; pp. 301 - 308
Main Authors Fonseca, Margarida, Barros, Francisca, Vaz, Raquel, Nunes, Ana, Cerqueira, Ana, Praca, Augusta, Sampaio, Susana
Format Journal Article
LanguagePortuguese
Published Sociedade Portuguesa de Nefrologia 01.12.2013
Subjects
UROLOGY & NEPHROLOGY
nefrite intersticial granulomatosa
granulomatous interstitial nephritis
prednisolone
Acute kidney injury
sarcoidosis
Lesao renal aguda
sarcoidose
prednisolona
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Abstract Sarcoidosis is a chronic inflammatory disorder of unknown cause. The histopathological feature is the presence of the non-caseating granuloma in any organ involved. The mechanisms most frequently implicated in renal dysfunction are due to disturbances in calcium metabolism; more rarely, granulomatous interstitial nephritis and glomerular disease may occur. The authors report three cases of sarcoidosis presented as interstitial nephritis with renal failure. Prednisolone treatment was performed at a dose of 1 mg/kg/day with partial and sustained recovery of renal function.
AbstractList Sarcoidosis is a chronic inflammatory disorder of unknown cause. The histopathological feature is the presence of the non-caseating granuloma in any organ involved. The mechanisms most frequently implicated in renal dysfunction are due to disturbances in calcium metabolism; more rarely, granulomatous interstitial nephritis and glomerular disease may occur. The authors report three cases of sarcoidosis presented as interstitial nephritis with renal failure. Prednisolone treatment was performed at a dose of 1 mg/kg/day with partial and sustained recovery of renal function.
Author Vaz, Raquel
Cerqueira, Ana
Sampaio, Susana
Fonseca, Margarida
Nunes, Ana
Barros, Francisca
Praca, Augusta
AuthorAffiliation Centro Hospitalar de São João
Hospital de Braga
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  givenname: Susana
  surname: Sampaio
  fullname: Sampaio, Susana
  organization: Centro Hospitalar de São João
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DocumentTitleAlternate Insuficiência renal como manifestação inaugural de sarcoidose: relato de três casos de nefrite intersticial e normocalcemia
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Keywords nefrite intersticial granulomatosa
granulomatous interstitial nephritis
prednisolone
Acute kidney injury
sarcoidosis
Lesao renal aguda
sarcoidose
prednisolona
Language Portuguese
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Title Renal sarcoidosis presenting as renal failure: report of three cases with interstitial nephritis and normocalcemia
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