Renal sarcoidosis presenting as renal failure: report of three cases with interstitial nephritis and normocalcemia

Sarcoidosis is a chronic inflammatory disorder of unknown cause. The histopathological feature is the presence of the non-caseating granuloma in any organ involved. The mechanisms most frequently implicated in renal dysfunction are due to disturbances in calcium metabolism; more rarely, granulomatou...

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Published inPortuguese journal of nephrology & hypertension Vol. 27; no. 4; pp. 301 - 308
Main Authors Fonseca, Margarida, Barros, Francisca, Vaz, Raquel, Nunes, Ana, Cerqueira, Ana, Praca, Augusta, Sampaio, Susana
Format Journal Article
LanguagePortuguese
Published Sociedade Portuguesa de Nefrologia 01.12.2013
Subjects
UROLOGY & NEPHROLOGY
nefrite intersticial granulomatosa
granulomatous interstitial nephritis
prednisolone
Acute kidney injury
sarcoidosis
Lesao renal aguda
sarcoidose
prednisolona
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Summary:Sarcoidosis is a chronic inflammatory disorder of unknown cause. The histopathological feature is the presence of the non-caseating granuloma in any organ involved. The mechanisms most frequently implicated in renal dysfunction are due to disturbances in calcium metabolism; more rarely, granulomatous interstitial nephritis and glomerular disease may occur. The authors report three cases of sarcoidosis presented as interstitial nephritis with renal failure. Prednisolone treatment was performed at a dose of 1 mg/kg/day with partial and sustained recovery of renal function.
ISSN:0872-0169