The pathology of acute Nolletia gariepina poisoning of cattle

Toxicity in cattle by the shrub Nolletia gariepina was induced experimentally by intraruminal administration of 3 g/kg dried, milled plant material as a single dose. The animals had to be starved for 24 hours before dosing, as dosing on a full rumen did not induce any signs of toxicity during 5 days...

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Published inJournal of the South African Veterinary Association Vol. 82; no. 3; pp. 144 - 149
Main Authors Du Plessis, E.C., Botha, C.J., Prozesky, L.
Format Journal Article
LanguageEnglish
Published AOSIS 01.09.2011
Subjects
Cattle
Clinical pathology
Nephrotoxicosis
Nolletia gariepina
Patyhology
South Africa
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Summary:Toxicity in cattle by the shrub Nolletia gariepina was induced experimentally by intraruminal administration of 3 g/kg dried, milled plant material as a single dose. The animals had to be starved for 24 hours before dosing, as dosing on a full rumen did not induce any signs of toxicity during 5 days of observation and clinical pathology monitoring. Clinical signs were not specific and varied according to the duration (acute versus subacute) of the toxicological process. Clinical pathological parameters indicated renal and to a lesser extent hepatic damage, with raised serum concentrations of urea, creatinine, aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT). Increased urinary sodium and potassium concentration and GGT activity, as well as proteinuria, were evident. Histological and electron microscopic examinations revealed acute renal tubular epithelial cell degeneration and necrosis, especially of the proximal convoluted tubules. Mild hepatocellular degeneration was also noticeable.
ISSN:1019-9128
2224-9435