NDM-1 has arrived : first report of a carbapenem resistance mechanism in South Africa : scientific letter

The New Delhi Metallo-β-lactamase (NDM) resistance mechanism in Enterobacteriaceae threatens to render serious Gram-negative infections untreatable. The NDM-1 enzyme hydrolyses all available penicillin, cephalosporin and carbapenem antibiotics, and is commonly accompanied by additional resistance me...

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Bibliographic Details
Published inSouth African medical journal Vol. 101; no. 12; pp. 873 - 875
Main Authors Bosman, N., Venturas, J., Clay, C., Duse, A., Lowman, W., Sriruttan, C., Coetzee, J., Nana, T.
Format Journal Article
LanguageEnglish
Published Health and Medical Publishing Group (HMPG) 01.12.2011
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Summary:The New Delhi Metallo-β-lactamase (NDM) resistance mechanism in Enterobacteriaceae threatens to render serious Gram-negative infections untreatable. The NDM-1 enzyme hydrolyses all available penicillin, cephalosporin and carbapenem antibiotics, and is commonly accompanied by additional resistance mechanisms to multiple antibiotic classes. Initially identified as a significant healthcare risk on the Indian sub-continent, it has rapidly become a global problem, posing significant diagnostic and management challenges. Here we report the first laboratory-confirmed case of NDM-1 in South Africa.
ISSN:0256-9574
2078-5135