Long-term dissolution of thermo- and pH-responsive, F magnetic resonance-traceable and injectable polymer implants

19 F magnetic resonance ( 19 F MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorin...

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Published inNanoscale advances Vol. 6; no. 12; pp. 341 - 351
Main Authors Jirát-Zió kowska, Natalia, Vít, Martin, Groborz, Ond ej, Kolouchová, Kristýna, ervený, David, Sedlá ek, Ond ej, Jirák, Daniel
Format Journal Article
Published 11.06.2024
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Summary:19 F magnetic resonance ( 19 F MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorinated implants designed for prolonged release. Implants were detected for 14 (intramuscular injection) and 20 (subcutaneous injection) months by 19 F MR at 4.7 T, showing favorable MR relaxation times, biochemical stability, biological compatibility and slow, long-term dissolution. Thus, polymeric implants may become a platform for long-term local theranostics. Thermo- and pH-responsive polymers' dissolution in vivo can be broadly fine-tuned. Polymeric implant can be detected in vivo using "hot-spot" 19 F MR measurement. Long-term in vivo dissolution of polymeric implant shows no side effects.
Bibliography:https://doi.org/10.1039/d4na00212a
Electronic supplementary information (ESI) available. See DOI
ISSN:2516-0230
DOI:10.1039/d4na00212a