Hydrazinosulfonylation of aryl electrophiles: a straightforward approach for the synthesis of aryl -aminosulfonamides

In recent years, the direct hydrazinosulfonylation of aryl electrophiles with SO 2 and hydrazines has emerged as an efficient and versatile method for the synthesis of aryl N -aminosulfonamides. This method has the advantages of being operationally simple and requiring only readily available startin...

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Published inRSC advances Vol. 13; no. 27; pp. 18546 - 1856
Main Authors Hsu, Chou-Yi, Obaid Aldulaimi, Ahmed Kareem, humam sami, Mustafa, Bahir, Hala, Adhab, Ayat Hussein, Saraswat, Shelesh Krishna
Format Journal Article
Published 20.06.2023
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Summary:In recent years, the direct hydrazinosulfonylation of aryl electrophiles with SO 2 and hydrazines has emerged as an efficient and versatile method for the synthesis of aryl N -aminosulfonamides. This method has the advantages of being operationally simple and requiring only readily available starting materials. This review article is an attempt to survey literature describing the preparation of aryl N -aminosulfonamides through the direct hydrazinosulfonylation of aryl electrophiles with SO 2 and hydrazines, with special attention paid to the mechanistic features of the reactions. It can be used as a guide for chemists to apply the best hydrazinosulfonylation conditions in their work or serve as inspiration for future research related to the topic. In recent years, the direct hydrazinosulfonylation of aryl electrophiles with SO 2 and hydrazines has emerged as an efficient and versatile method for the synthesis of aryl N -aminosulfonamides.
ISSN:2046-2069
DOI:10.1039/d3ra03123c