Expeditious preparation of β--alkyl vicinal amino alcohols used for chiral ligand synthesis

An economical route providing quick access to chiral β-amino alcohols bearing one β- sec -alkyl group was developed. This protocol starts with commercially available and cheap chiral sources such as derivatives of l -serine and l -threonine. A series of vicinal amino alcohols with high optical purit...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 21; no. 3; pp. 6111 - 6114
Main Authors Huang, Guoqi, Wu, Yu, Gong, Hegui, Chen, Yunrong
Format Journal Article
Published 02.08.2023
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Summary:An economical route providing quick access to chiral β-amino alcohols bearing one β- sec -alkyl group was developed. This protocol starts with commercially available and cheap chiral sources such as derivatives of l -serine and l -threonine. A series of vicinal amino alcohols with high optical purity were prepared in good yields through 4 or 6 operationally simple steps. Two different strategies (three routes) were designed for the synthesis of amino alcohols bearing β- sec -alkyl groups with various steric hindrance. An economical route providing quick access to chiral vicinal amino alcohols bearing a symmetric β- sec -alkyl group was developed.
Bibliography:https://doi.org/10.1039/d3ob00803g
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob00803g