Inducing and monitoring mitochondrial pH changes with an iridium() complex two-photon lifetime imaging

Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium( iii ) complex MitoIr-NH has been explored as a novel anticancer agent. Mit...

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Bibliographic Details
Published inDalton transactions : an international journal of inorganic chemistry Vol. 52; no. 43; pp. 15859 - 15865
Main Authors Hu, Meng, Zhou, Xin-Lan, Xiao, Tian-Xin, Hao, Liang, Li, Yi
Format Journal Article
Published 07.11.2023
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Summary:Real-time monitoring of mitochondrial dynamic changes plays a key role in the development of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and mitochondria-targeted cyclometalated iridium( iii ) complex MitoIr-NH has been explored as a novel anticancer agent. MitoIr-NH displayed pH-responsive phosphorescence intensity and lifetime, accumulated in mitochondria, showed higher antiproliferative activity and induced a series of mitochondria-related events. Moreover, MitoIr-NH could simultaneously induce mitophagy and quantitatively monitor mitochondrial pH changes through two-photon phosphorescence lifetime imaging microscopy (TPPLIM) in a real-time manner. A pH-responsive cyclometalated iridium( iii ) complex has been explored to induce and monitor mitophagy simultaneously by two-photon phosphorescence lifetime imaging microscopy.
Bibliography:https://doi.org/10.1039/d3dt02541a
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-9226
1477-9234
DOI:10.1039/d3dt02541a