Selective confinement of potassium, rubidium, or caesium ions in a non-covalent hydroxyproline octamer cage stabilized by -hydroxyl locks

• Published in: Physical chemistry chemical physics : PCCP Vol. 25; no. 34; pp. 22614 - 22618
• Main Authors: Hou, Yameng, Zhou, Sijin, Xu, Xingshi, Kou, Min, Kong, Xianglei
• Format: Journal Article
• Published: 30.08.2023
• ISSN: 1463-9076; 1463-9084
• DOI: 10.1039/d3cp03230b

While numerous studies have focused on the impact of chirality on some magic amino acid clusters, this article investigates the effects of steric isomerization using 4-hydroxyproline octamers as a model system. Through mass spectrometry, infrared photodissociation spectroscopy, and theoretical calculation, it was demonstrated that the cis -4-hydroxy- l -proline octamer can selectively cage potassium, rubidium, or caesium ions through stable cis -hydroxyl locks, while the trans -form cannot. The results highlight the importance of hydroxyl group orientation in designing biocompatible membrane transporters with high ion-selectivity. While numerous studies have focused on the impact of chirality on some magic amino acid clusters, this article investigates the effects of steric isomerization using 4-hydroxyproline octamers as a model system.