Pd()-Catalyzed enantioselective C-H olefination toward the synthesis of -stereogenic phosphinamides

P -Stereogenic phosphorus compounds are important structural elements in chiral ligands or organocatalysts. Herein, we report a Pd( ii )-catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphinamides using cheap commercially available l - p Glu-OH as a chiral ligand...

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Published inChemical communications (Cambridge, England) Vol. 6; no. 12; pp. 1623 - 1626
Main Authors Chen, Zi-Jia, Fan, Ling-Jie, Xie, Pei-Pei, Qian, Pu-Fan, Hu, Xinquan, Zhou, Tao, Shi, Bing-Feng
Format Journal Article
Published 06.02.2024
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Summary:P -Stereogenic phosphorus compounds are important structural elements in chiral ligands or organocatalysts. Herein, we report a Pd( ii )-catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphinamides using cheap commercially available l - p Glu-OH as a chiral ligand. A broad range of P -stereogenic phosphinamides were gained in good yields with high enantioselectivities (33 examples, up to 77% yield, 99% ee) via desymmetrization and kinetic resolution. A Pd( ii )-catalyzed enantioselective C-H olefination toward the synthesis of P -stereogenic phosphines is reported.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
2183918
https://doi.org/10.1039/d3cc05052a
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05052a