DMSO-KOH mediated stereoselective synthesis of -enamides: an expeditious route to -enamide bearing natural products

An efficient strategy towards stereoselective amidation of alkynes is reported. The given method features operational simplicity, excellent functional group tolerance, broad substrate scope and fast kinetics to furnish Z -enamides. Moreover, the method was successfully applied for the facile synthes...

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Published inChemical communications (Cambridge, England) Vol. 6; no. 1; pp. 114 - 117
Main Authors Bhat, Showkat Ahmad, Ahmed, Qazi Naveed, Bhat, Khursheed Ahmad
Format Journal Article
Published 19.12.2023
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Summary:An efficient strategy towards stereoselective amidation of alkynes is reported. The given method features operational simplicity, excellent functional group tolerance, broad substrate scope and fast kinetics to furnish Z -enamides. Moreover, the method was successfully applied for the facile synthesis of the natural products lansiumamide A, lansiumamide B and Z -alatamide. Notably, DMSO plays two vital roles: hydrogen source and solvent. An efficient strategy towards stereoselective amidation of alkynes is reported.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
2247294
https://doi.org/10.1039/d3cc04642g
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc04642g