Synthesis of trifluoromethyl ,-aminals from nitrogen containing heterocycles by using a plasma flow microreactor

Trifluoromethyl N , N -aminals are important precursors allowing access to fluorinated building blocks. In this work, the direct synthesis of trifluoromethyl N , N -aminals from nitrogen containing heterocycles is reported using argon plasma in a continuous flow microreactor without any additives or...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 28; pp. 4213 - 4216
Main Authors Abedelnour, Elias, Ognier, Stephanie, Venier, Olivier, Schio, Laurent, Tatoulian, Michael, Cossy, Janine
Format Journal Article
Published 04.04.2023
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Summary:Trifluoromethyl N , N -aminals are important precursors allowing access to fluorinated building blocks. In this work, the direct synthesis of trifluoromethyl N , N -aminals from nitrogen containing heterocycles is reported using argon plasma in a continuous flow microreactor without any additives or metal catalysts. Their transformation to N -trifluoroethyl amines is also reported. Trifluoromethyl N , N -aminals were synthesized from nitrogen containing heterocycles in a R 3 SiCF 3 solution, using an argon plasma in a flow microreactor. The transformation of the trifluoromethyl N , N -aminals to N -trifluoroethylamine is also reported.
Bibliography:Electronic supplementary information (ESI) available: Containing procedures, IR, NMR, GCMS and HRMS data. See DOI
https://doi.org/10.1039/d3cc00942d
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00942d