Advancements in the development of fluorescent chemosensors based on C&z.dbd;N bond isomerization/modulation mechanistic approaches
The C&z.dbd;N bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules. From the beginning, the C&z.dbd;N bond isomerization method has attracted the attention of researchers owing to i...
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| Published in | Analytical methods Vol. 16; no. 15; pp. 2198 - 2228 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Published |
18.04.2024
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| Online Access | Get full text |
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| Summary: | The C&z.dbd;N bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules. From the beginning, the C&z.dbd;N bond isomerization method has attracted the attention of researchers owing to its simplicity, high selectivity, and sensitivity in fluorescence evaluation. Continuous developments in the field of sensing using C&z.dbd;N bond-containing compounds have been achieved
via
the customization of the isomerization process around the C&z.dbd;N bond in numerous ways, and the results were obtained in the form of specific discrete photophysical changes. C&z.dbd;N isomerization causes significant fluorescence enhancement in response to detected metal cations and other reactive species (Cys, Hys, ClO
−
,
etc.
) straightforwardly and effectively. This review sheds light on the process of C&z.dbd;N bond isomerization/modulation as a signalling mechanism depending on fluorescence changes
via
conformational restriction. In addition, C&z.dbd;N bond isomerization-based fluorescent sensors have yet to be well reviewed, although several fluorescent sensors based on this signalling mechanism have been reported. Therefore, C&z.dbd;N-based fluorescent sensors are summarized in this review.
The C&z.dbd;N bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules. |
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| Bibliography: | Mr Ankur Srivastava completed his MSc (2014) in Chemistry from Dr Ram Manohar Lohia Avadh University Ayodhya, India. He is pursuing his PhD, from the Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India, under the supervision of Prof. Mrituanjay D. Pandey and Dr Jay Singh. His research interests are in Materials Science and Inorganic Chemistry for the synthesis of nanomaterials, metal oxides, quantum dots and biosensing applications. Dr Manzoor Ahmad Wani completed his MSc (2012) in Chemistry from DAVV Indore and MPhil (2013) from Bundelkhand University, Jhansi. He completed his PhD (2017) in Chemistry from Dr Harisingh Gour University, Sagar, MP, under the supervision of Prof. Mrituanjay D. Pandey and Dr Rampal Pandey. His research interests include the design, synthesis and structural studies of fluorogenic, organic and metal complex-based molecular probes for the metal ions of biological and environmental values. Mrs Gargi Mishra completed her master's degree in biotechnology from H.N.B. Garhwal University, Uttarakhand. After finishing her master's, she worked as a research officer at the National Cancer Center, Singapore. She joined the Department of Chemistry, Institute of Science, Banaras Hindu University, for the doctoral degree program under the supervision of Prof. Mrituanjay D. Pandey. Her research work is focused on investigating structural variation within the biomolecular framework. She is also interested in developing biomolecular probes for the detection of heavy metals. Dr Rampal Pandey is Assistant Professor & Head, Department of Chemistry, National Institute of Technology Uttarakhand. Erstwhile, he has served as DST Inspire Faculty at Dr Harisingh Gour Vishwavidyalaya Sagar and Research Associate (RA) at Banaras Hindu University (BHU), Varanasi. He obtained his PhD at BHU and his MSc from APS University, Rewa, India. He has over 15 years of teaching and research experience. He has research/academic projects worth ∼50 Lakhs (INR) and thirteen awards/recognitions/appreciations to his credit, including prestigious Inspired Teacher Recognition. Dr Pandey has published more than 55 research papers and has been granted 02 patents. He has served as a coordinator for Massive Open Online Courses (MOOCs) and content writer for the e-PG-Pathshala programme of the Ministry of Education. He is a member of the American Chemical Society, Royal Society of Chemistry, Society of Materials Chemistry, Solar Energy Society of India, and Indian Society of Chemists and Biologists. He is a section editor, academic editor and potential reviewer for several journals of ACS, RSC, Wiley Intersciences and Elsevier. Ms Arpna Tamrakar completed his MSc (2016) in Chemistry from Dr Harisingh Gour Vishwavidyalaya Sagar (MP), India. She is pursuing her PhD at the Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India, under the supervision of Prof. Mrituanjay D. Pandey. Her research interests include Inorganic Chemistry and Bio-inspired Materials for Sensing and Catalytic Applications. Dedicated to Prof. Parimal K. Bharadwaj (IIT Kanpur) for his outstanding contribution to Supramolecular Chemistry. Prof. Mrituanjay D. Pandey is Professor of Chemistry at BHU Varanasi, India. He received his PhD in Chemistry from the University of Allahabad. He completed a successful research stay at IIT Delhi, IIT Kanpur, UJI Castellon, Dr Harisingh Gour University Sagar, and Delhi University. His research interest is Inorganic and Organometallic Chemistry, focusing on Building Sustainable Bio-Inspired Designs for Sensing, Catalysis, Energy, and Biomedical Applications. |
| ISSN: | 1759-9660 1759-9679 |
| DOI: | 10.1039/d3ay02321d |