BF·EtO-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides

Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF 3 ·Et 2 O. This protocol features good functional tolerance and ease of operation, to open a route to...

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Bibliographic Details
Published inRSC advances Vol. 12; no. 37; pp. 24237 - 24241
Main Authors Cheng, Zhenfeng, Gu, Qingyun, Xie, Yushan, Zhang, Yanan, Zeng, Xiaobao
Format Journal Article
Published 25.08.2022
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Summary:Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF 3 ·Et 2 O. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides via an annulation and dehydration process. An efficient approach to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides via annulation reaction of α-keto acids with simple aliphatic ketones is reported herein.
Bibliography:Electronic supplementary information (ESI) available. CCDC
2182801
For ESI and crystallographic data in CIF or other electronic format see
https://doi.org/10.1039/d2ra04546j
ISSN:2046-2069
DOI:10.1039/d2ra04546j