Aza-[4 + 2] cycloadditions employing catalytically derived -acyliminium ions

Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf 2 ) 2 / n Bu 4 NPF 6 catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in pre...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 2; no. 42; pp. 829 - 8211
Main Authors Owen, Niamh J, McLaughlin, Mark G
Format Journal Article
Published 02.11.2022
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Summary:Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf 2 ) 2 / n Bu 4 NPF 6 catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in predominantly good yields. An aza-[4 + 2] cycloaddition employing N -acyliminium ions is reported, allowing access to novel fused ring systems.
Bibliography:https://doi.org/10.1039/d2ob01663j
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01663j