Sustainable access to benzothiophene derivatives bearing a trifluoromethyl group a three-component domino reaction in water

A catalyst-free three-component domino reaction was developed for the synthesis of benzothiophene fused pyrrolidones bearing a CF 3 group for the first time. The notable advantages of this strategy over the existing methods include the use of water as a solvent at room temperature, transition metal-...

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Published inOrganic & biomolecular chemistry Vol. 2; no. 37; pp. 7424 - 7428
Main Authors Deng, Qingsong, Gu, Jun, Zhang, Huan, Zhang, Youlai, Meng, Xiangtai
Format Journal Article
Published 28.09.2022
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Summary:A catalyst-free three-component domino reaction was developed for the synthesis of benzothiophene fused pyrrolidones bearing a CF 3 group for the first time. The notable advantages of this strategy over the existing methods include the use of water as a solvent at room temperature, transition metal-free conditions, a broad substrate scope, and easy scale-up synthesis. More importantly, the benzothiophene derivatives have been found to show potent anticancer activities using the Cell Counting Kit-8 (CCK-8) assay. A catalyst-free three-component domino reaction was developed for the synthesis of benzothiophene fused pyrrolidones bearing a CF 3 group in water at room temperature.
Bibliography:C NMR spectra for new compounds. CCDC
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For ESI and crystallographic data in CIF or other electronic format see DOI
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https://doi.org/10.1039/d2ob01034h
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Electronic supplementary information (ESI) available: Experimental details and characterization of all new compounds and copies of
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01034h