Highly efficient and fast synthesis of di-iodinated succinimide derivatives from 1,6-enyne and I under air at room temperature

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 24; no. 2; pp. 821 - 828
• Main Authors: Lu, Yuling, Chen, Chunmei, Zhu, Hucheng, Luo, Zengwei, Zhang, Yonghui
• Format: Journal Article
• Published: 18.10.2022
• ISSN: 1463-9262; 1463-9270
• DOI: 10.1039/d2gc02058k

Without using any additives, a green and efficient procedure for the preparation of valuable di-iodinated succinimide derivatives has been achieved through the iodine radical-initiated cascade cyclization of 1,6-enynes. This protocol could be conducted in MeCN in open air at room temperature with good to excellent yields. Notably, this method is highly atom- and time-economical, safe to operate, easy to scale up, and has excellent functional group compatibility. Moreover, this is the first example of di-iodinolysis cyclization using iodine radical cascade reaction. A metal-free, additive-free, and practical method for the synthesis of diiodinated succinimide derivatives has been achieved under mild conditions.