Highly efficient and fast synthesis of di-iodinated succinimide derivatives from 1,6-enyne and I under air at room temperature
Without using any additives, a green and efficient procedure for the preparation of valuable di-iodinated succinimide derivatives has been achieved through the iodine radical-initiated cascade cyclization of 1,6-enynes. This protocol could be conducted in MeCN in open air at room temperature with go...
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Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 24; no. 2; pp. 821 - 828 |
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Main Authors | , , , , |
Format | Journal Article |
Published |
18.10.2022
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Online Access | Get full text |
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Summary: | Without using any additives, a green and efficient procedure for the preparation of valuable di-iodinated succinimide derivatives has been achieved through the iodine radical-initiated cascade cyclization of 1,6-enynes. This protocol could be conducted in MeCN in open air at room temperature with good to excellent yields. Notably, this method is highly atom- and time-economical, safe to operate, easy to scale up, and has excellent functional group compatibility. Moreover, this is the first example of di-iodinolysis cyclization using iodine radical cascade reaction.
A metal-free, additive-free, and practical method for the synthesis of diiodinated succinimide derivatives has been achieved under mild conditions. |
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Bibliography: | https://doi.org/10.1039/d2gc02058k Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1463-9262 1463-9270 |
DOI: | 10.1039/d2gc02058k |