Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents

Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor...

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Published inChemical communications (Cambridge, England) Vol. 58; no. 91; pp. 12676 - 12679
Main Authors Wang, Meng-Fan, Deng, Yu-Ang, Li, Qing-Fang, Tang, Shi-Jie, Yang, Rong, Zhao, Run-Yu, Liu, Fu-Dan, Ren, Xiaoxia, Zhang, Dan, Gao, Feng
Format Journal Article
Published 15.11.2022
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Summary:Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor photothermal therapy agent in vitro and in vivo . Mitochondrion-targeting dinuclear osmium complexes with extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser without nucleus affinity and photodynamic activity act as antitumor photothermal therapy agents in vivo .
Bibliography:Electronic supplementary information (ESI) available: Synthesis, characterization, and experimental procedures. See DOI
https://doi.org/10.1039/d2cc05230j
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc05230j