Synergistically activated dual-locked fluorescent probes to monitor HS-induced DNA damage
Naphthalimide-based fluorescent probes ( NAN0-N 3 and NAN6-N 3 ) were developed with dual locked fluorescence. Here, ≥1.9 × 10 −2 mM of H 2 S and ≥2.2 × 10 −2 μg mL −1 of DNA could unlock a highly sensitive off-on fluorescence response through synergistic changes of the molecular structure and confo...
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| Published in | Chemical communications (Cambridge, England) Vol. 58; no. 75; pp. 15 - 153 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Published |
20.09.2022
|
| Online Access | Get full text |
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| Summary: | Naphthalimide-based fluorescent probes (
NAN0-N
3
and
NAN6-N
3
) were developed with dual locked fluorescence. Here, ≥1.9 × 10
−2
mM of H
2
S and ≥2.2 × 10
−2
μg mL
−1
of DNA could unlock a highly sensitive off-on fluorescence response through synergistic changes of the molecular structure and conformation. As such, the probes could monitor DNA damage induced by the overexpression of H
2
S, and were able to evaluate the degree of apoptosis of living cells mediated by H
2
S-induced mtDNA or nDNA damage.
NAN0-N
3
and
NAN6-N
3
could monitor DNA damage induced by the overexpression of H
2
S. |
|---|---|
| Bibliography: | https://doi.org/10.1039/d2cc04247a Electronic supplementary information (ESI) available. See DOI |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/d2cc04247a |