Asymmetric synthesis of planar-chiral macrocycles organocatalyzed enantioselective macrocyclization
A novel enantioselective macrocyclization method has been developed for the asymmetric synthesis of planar-chiral macrocycles through chiral phosphoric acid-catalyzed intramolecular addition of the hydroxy group with the allenamide moiety. A series of planar-chiral macrocycles bearing various ring s...
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Published in | Chemical communications (Cambridge, England) Vol. 58; no. 52; pp. 7293 - 7296 |
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Main Authors | , , , |
Format | Journal Article |
Published |
28.06.2022
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Online Access | Get full text |
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Summary: | A novel enantioselective macrocyclization method has been developed for the asymmetric synthesis of planar-chiral macrocycles through chiral phosphoric acid-catalyzed intramolecular addition of the hydroxy group with the allenamide moiety. A series of planar-chiral macrocycles bearing various ring sizes (18-member to 22-member) and various functional groups were generated with good to high enantioselectivities.
A novel enantioselective macrocyclization method has been developed for the asymmetric synthesis of planar-chiral macrocycles through chiral phosphoric acid-catalyzed intramolecular addition of the hydroxy group with the allenamide moiety. |
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Bibliography: | Electronic supplementary information (ESI) available. CCDC For ESI and crystallographic data in CIF or other electronic format see DOI 2160358 https://doi.org/10.1039/d2cc01690g |
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d2cc01690g |