Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium salts regioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional gr...

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Published inOrganic & biomolecular chemistry Vol. 19; no. 36; pp. 7832 - 7837
Main Authors Venkatesh, Rapelly, Singh, Adesh Kumar, Lee, Yong Rok, Kandasamy, Jeyakumar
Format Journal Article
Published 22.09.2021
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Summary:Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers. Synthesis of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described at room temperature. The reaction is catalyzed by palladium acetate in the absence of ligands and base.
Bibliography:Electronic supplementary information (ESI) available: NMR Spectra is available for all the products. See DOI
10.1039/d1ob01503f.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob01503f