Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of
Panax notoginseng has been used both as a traditional medicine and as a functional food for hundreds of years in Asia. However, the active constituents from P. notoginseng and their pharmacologic properties still need to be further explored. In this study, one new dammarane-type triterpenoid saponin...
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| Published in | Food & function Vol. 13; no. 6; pp. 359 - 362 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Published |
21.03.2022
|
| Online Access | Get full text |
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| Summary: | Panax notoginseng
has been used both as a traditional medicine and as a functional food for hundreds of years in Asia. However, the active constituents from
P. notoginseng
and their pharmacologic properties still need to be further explored. In this study, one new dammarane-type triterpenoid saponin (
1
), along with fourteen known analogs (
2-15
) were isolated and identified from the roots of
P. notoginseng
. The anti-inflammatory, anti-angiogenetic and anti-dengue virus effects of these isolated compounds were further evaluated. Compounds
1
,
3
,
5-7
and
10-12
exerted anti-inflammatory effects in two different zebrafish inflammatory models. Among them,
11
, with the most significant activities, alleviated the inflammatory response by blocking the MyD88/NF-κB and STAT3 pathways. Moreover, compound
15
showed anti-angiogenetic activities in Tg(
fli1:EGFP
) and Tg(
flk1:GFP
) zebrafish, while
3
and
5
only inhibited angiogenesis in Tg(
fli1:EGFP
) zebrafish. Additionally, compounds
1
,
3
,
6
,
8
,
9
and
12
suppressed the replication of dengue virus either at the viral adsorption and entry stages or at the intracellular replication step. In conclusion, these findings enrich knowledge of the diversity of saponins in
P. notoginseng
and suggest that the dammarane-type triterpenoid saponins from
P. notoginseng
may be developed as potential functional foods to treat inflammation, angiogenesis or dengue-related diseases.
Fifteen dammarane-type triterpenoid saponins including one new compound isolated from
P. notoginseng
exhibited anti-inflammatory, anti-angiogenetic and antiviral activities. |
|---|---|
| Bibliography: | 10.1039/d1fo04089h Electronic supplementary information (ESI) available. See DOI |
| ISSN: | 2042-6496 2042-650X |
| DOI: | 10.1039/d1fo04089h |